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Cluster Sets for Hypertrophy
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Cluster Sets for Hypertrophy

Are they any better than traditional sets for building muscle?

Danny James's avatar
Danny James
Mar 10, 2025
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Cluster Sets for Hypertrophy
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Strong male athlete wearing a light blue T-shirt is taking a break between sets.
Image created using Midjourney.

This study compared the effects of cluster sets (CS) and traditional sets (TS) on muscle growth in resistance-trained individuals, addressing the limitations of previous research by matching effort levels between protocols.

Key Points

  • CS involve breaking up a set into smaller clusters with short rest periods

  • Previous studies comparing CS and TS often didn't match effort levels, potentially biasing results

  • This study matched sets, reps, and effort (measured by repetitions in reserve) between CS and TS

Aim

To compare muscle hypertrophy between CS and TS protocols when matched for volume and effort.

Methods

  • 10 resistance-trained participants (7 men, 3 women)

  • 8-week training period, 2 sessions per week

  • Unilateral design: one leg did CS, the other did TS

  • CS: 5 sets of 3 clusters of 4 reps with 20s rest between clusters

  • TS: 5 sets of 12 reps

  • Both protocols adjusted load to 0-1 repetitions in reserve

  • Measured muscle thickness via ultrasound and lean mass via DXA

Results

  • Both CS and TS led to similar increases in muscle thickness (p < 0.001, ES = 0.56 for CS; p = 0.012, ES = 0.42 for TS)

  • Both protocols resulted in similar increases in lean tissue mass (p = 0.002, ES = 0.11 for CS; p < 0.001, ES = 0.13 for TS)

Practical Takeaways

  1. CS can be an effective alternative to TS for muscle growth

  2. When effort is matched, CS and TS produce similar hypertrophy

  3. CS may allow for higher loads while maintaining effort, potentially benefiting strength gains

  4. Lifters can use CS to add variety to their training without sacrificing muscle growth


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