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5 Best Sports Supplements

A narrative review of what works and what's safe.

Danny James's avatar
Danny James
May 02, 2025
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A full shelf of sports supplements.
Image created using Midjourney.

The study "The Top 5 Can't-Miss Sport Supplements" by Curtis et al. (2024) examines five of the most effective ergogenic aids in sports nutrition: creatine, beta-alanine, nitrates, caffeine, and protein. This comprehensive review analyses these supplements' efficacy, mechanisms of action, and practical applications for enhancing athletic performance.

PMID: 39408214

Key Points

  1. The study focuses on supplements with robust evidence for efficacy and safety.

  2. Each supplement offers unique benefits for different aspects of athletic performance.

  3. Dosage recommendations and timing strategies are provided for optimal results.

Aim

The primary objective of this narrative review is to provide an updated analysis of the scientific evidence supporting the use of these five supplements as ergogenic aids in sports and exercise.

Methods

The authors conducted a narrative review of the literature, focusing on the most recent and relevant studies demonstrating the efficacy and safety of creatine, beta-alanine, nitrates, caffeine, and protein supplementation in athletic performance.

Results

Creatine

  • Increases phosphocreatine stores in skeletal muscles

  • Enhances ATP production during high-intensity exercises

  • Improves skeletal muscle mass, strength/power, and muscular endurance

  • Typical dosage: 3-5 g per day

  • Safe for long-term use


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Beta-alanine

  • Elevates intramuscular carnosine levels

  • Acts as a buffer in skeletal muscles, delaying fatigue during high-intensity exercise

  • Recommended dosage: 2-6 g daily in divided doses

  • Significant performance improvements in activities lasting 1-4 minutes

Nitrates

  • Enhances aerobic performance by increasing oxygen delivery to muscles

  • Improves endurance and reduces oxygen cost during exercise

  • Recommended dosage: approximately 500 mg taken 2-3 hours before exercise

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